Anthelminthic Activity of Annona reticulata Seed Extracts

Kumar, D. R. Yashwanth and Vedamurthy, A. B. and Hoskeri, H. Joy (2014) Anthelminthic Activity of Annona reticulata Seed Extracts. British Journal of Pharmaceutical Research, 4 (6). pp. 669-675. ISSN 22312919

[thumbnail of Kumar462013BJPR6055.pdf] Text
Kumar462013BJPR6055.pdf - Published Version

Download (305kB)

Abstract

Aims: To evaluate the anthelminthic activity of Annona reticulata seeds extracts against Pheretima posthuma.
Study Design: Helminth infections have tormented humans and animals for thousands of years. The indiscriminate uses of the anthelminthic drugs have lead to the emergence of resistant helminths against many anthelminthic agents. Thus the need for the treatment of helminthic infections and the prevention of the emergence of resistant strains has led to the screening medicinal plants for their anthelminthic activity.
Place and Duration of Study: Department of Biotechnology, The Oxford College of Science, Bangalore, Karnataka, India, between January 2012 and March 2012.
Methodology: The main aim of the present exploratory study is to evaluate the anthelminthic activity of A. reticulata seeds extracts. The in vitro studies revealed that the anthelminthic effects of crude chloroform and ethanolic extracts of A. reticulata on Pheretima posthuma was evident from induction of paralysis and mortality. Piperazine citrate was used as the standard reference drug and normal saline as a control group.
Results: Among all the concentrations of chloroform and ethanolic extracts tested, 12.5 mg/ml showed significant (p<0.01) anthelminthic activity. The results indicated that the ethanolic extract of A. reticulata is a more potent anthelminthic agent against Pheretima posthuma when compared with chloroform extract but less potent when compared with the standard drug.
Conclusions: The results of this investigation justifies the use of the seed extracts of A. reticulata in traditional medical practice for the treatment of helminth infections.

Item Type: Article
Subjects: Research Scholar Guardian > Medical Science
Depositing User: Unnamed user with email support@scholarguardian.com
Date Deposited: 12 Jan 2024 05:04
Last Modified: 12 Jan 2024 05:04
URI: http://science.sdpublishers.org/id/eprint/1194

Actions (login required)

View Item
View Item