A Straightforward and Receptive UV Spectrophotometric Method for the Determination of Ibandronate Sodium in Pharmaceutical Formulations and Bulk Drugs

Aims: A uncomplicated and outlay efficient spectrophotometric method is developed for the determination of Ibandronate sodium in unadulterated form and in pharmaceutical formulations.

Place and Duration of Study: Department of Pharmacognosy and Ethnopharmacology Division (Pilot plant), CSIR-NBRI, Lucknow, India and Integral University up to 6 month.

Methodology: The drug was highly soluble in sodium hydroxide (NaOH) so it was selected as the solvent system for the drug. This method determines sufficient solubility of drug and assay sensitivity. The linearity range for Ibandronate sodium at its wavelength of detection of 215 nm was obtained as 25–200 μg/ml. The linear regression equation determined by least square regression method, were Y =0.0011X + 0.034, where Y is the absorbance and X is the concentration (in μg/ml) of pure drug solution.

Results: The absorbance be set up to rise linearly with increasing concentration of Ibandronate sodium, which is obtained by the calculated correlation coefficient value of 0.9999. The limit of detection and limit of quantification was set up to 8.6900 μg/ ml & 26.333 μg /ml respectively.

Conclusion: The validity of the determined procedure was assessed. Statistical analysis of the result shows elevated accuracy and good precision. The proposed method was effectively applied to the fortitude of Ibandronate sodium in pharmaceutical formulations without any interference from ordinary excipients.