Regulation of angiogenesis in experimental myocardial infarction zone by application of multipotent mesenchymal stem cells

In the experiment on myocardial infarction (MI), pathophysiological aspects and heart remodeling processes was carried out. It was shown that VEGF and FGF is the most promising angiogenic factors in MI. It has been shown that the use of multipotent mesenchymal stem cells is an effective method of influence on regulation of angiogenesis by increasing the angiogenic factors. Therapeutic effect of multipotent mesenchymal stem cells is achieved due to the stimulation of neoangiogenesis, increasing of the number of vessels and the diminishment of the area of the scar. Our data are consistent with the world literature that can be recommended to use of this type of cellular cardiomyoplasty in the future clinic research.