SYNTHESIS AND CHARACTERIZATION OF THE COMPLEXES OF ISOVALERIC ACID HYDRAZIDE WITH M (II) NITRATES (M= Co, Ni, Cu)

Complexes of isovaleric acid hydrazide (IVH) with M (II) nitrates have been synthesized (M = Co, Ni and Cu). The ligand was characterized by melting point and IR studies, while the complexes were characterized by melting point, conductance, IR and electronic Spectral studies. The ligand, complexes and metal salts were screened for antimicrobial activity. The electronic data indicates octahedral coordination for Co2+, Ni2+ and Cu2+ complexes. Infrared spectra data are diagnostic of bidentate coordination for the ligand. They coordinate via the carbonyl oxygen atom and the primary amino nitrogen atom. The NO3- and Cl- anions are in the outer coordination sphere. Minimum activity was shown by the complexes with some microbes while with others are insignificant, as compared with the metal salts except for [Ni (IVH)2](NO3)2.H2O that showed significant activity against Staph. aureus and E. coli. Conductivity studies indicate a non-electrolytic nature for the complexes while the high melting/decomposition temperature indicates a polymeric nature of the complexes.