Critical Overview on Primary Lymphoepitheliomalike Carcinoma of the Prostate Gland: A Review of the Literature

Background: Primary lymphoepithelioma-like carcinoma of the prostate gland (PLELCP) is rare with
hardly any information on its diagnostic features and biological behaviour.
Aim: To review the literature.
Methods: Various Internet data bases were searched.
Literature Review: PLELCP is extremely rare and there are hardly any pictures of the tumour
involving the prostate; hence it would appear that clinicians would need to use their knowledge of the
microscopic and immunohistochemical characteristics of the tumour in the nasopharynx and urinary
bladder as diagnostic aid. PLELCP on microscopy mimics nasopharyngeal LELC. The LELC
component of the tumour is characterized by indistinct cytoplasmic borders and a syncytial growth
pattern. The stroma may be densely infiltrated by lymphoid cells admixed with some plasma cells and
neutrophils and at times prominent infiltration of eosinophils. PLELCPs tend to have adenocarcinoma,
either as the only pattern or with additional ductal components or adenosquamous carcinoma.
PLELCPs stain positively with PSA, PSAP, AMACR/P504S, EMA, and cytokeratins AE1/AE3, 7, 8,
and 20. There is no consensus on treatment of PLECP. The reported prognosis has been poor.
Conclusions: PLELCPs should be entered into a multicenter trial to determine the biological
behaviour and to find the best treatment option that would improve the prognosis.