POTENTIAL IMPACT OF TIME ON DNA DAMAGE, MICRONUCLEUS WITH LIVER CONTENTS AND FUNCTION AFTER PARTIAL HEPATECTOMY IN RATS

Liver regeneration after partial hepatectomy (PH) is one of the most captivating phenomena in medicine. The aim of this work was to study the effect of time (days) on DNA damage, micronucleus, liver contents (weight, water and lipid %) and function after PH in male rats was evaluated. Liver weight, water and lipid contents as well transaminases enzymes, bilirubin (BR) and protein were determined. In addition, DNA fragmentation, micronucleus (Mn) induction and hemoglobin were also assessed. Liver weight was decreased significantly and restored to normal by day 3. However, lipid content was increased significantly but restored to normal by day 7. Water content was similarly increased in regenerating liver and restored the normal by day 28. Transaminases, Brill and protein levels were decreased and restored to normal by day 14. In addition, hemoglobin was decreased and restored to normal by day 28. DNA fragmentation and micronucleus frequency were increased significantly compared to control (day 0) and restored to normal on day 7 and 28 for DNA and Mn, respectively. In conclusion, liver regeneration in male rats after 70% partial hepatectomy (PH), response at 3rd, 7th, and 14th days. Our results might be of clinical relevance for human medicine.