Interactions of Downregulated Proteins in MCF-7 Cells, Treated with Resveratrol

With over 600,000 breast cancer deaths/year, breast cancer, the age-old disease is still an unmet need for many women worldwide. Considering the cost and severe side effects of the commonly administered chemotherapeutic drugs, use of natural compounds, such as resveratrol, available in grapes and many other plants is a viable alternative that is gentle on both the physique and the purse. Towards this, the purpose of this study is to analyze the interactions of the downregulated proteins in MCF-7, the human estrogen receptor positive cell line, when treated with resveratrol, using string interaction diagrams and the corresponding gene ontology functional enrichments and pathways. Results indicate that Resveratrol, with its various anticancer attributes could be a potential anticancer agent and more work needs to be done towards that.