Miquelianin Inhibits Allergic Responses in Mice by Suppressing CD4+ T Cell Proliferation

Choi, Dae Woon and Jung, Sun Young and Kim, Gun-Dong and Lee, So-Young and Shin, Hee Soon (2021) Miquelianin Inhibits Allergic Responses in Mice by Suppressing CD4+ T Cell Proliferation. Antioxidants, 10 (7). p. 1120. ISSN 2076-3921

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Abstract

Allergic diseases, including atopic dermatitis (AD), induce type 2 helper T (Th2) cell-dominant immune responses. Miquelianin (quercetin 3-O-glucuronide, MQL) is an active compound in Rosae multiflorae fructus extract with anti-allergic properties. Here, we investigate the anti-allergic effects of MQL in an ovalbumin (OVA)-induced Th2-dominant mouse model and the associated mechanisms. Oral MQL suppressed cytokine and IL-2 production and proliferation of Th2 cells and upregulated heme oxygenase-1 (HO-1) in splenocytes. Ex vivo MQL suppressed Th1- and Th2-related immune responses by inhibiting CD4+ T cell proliferation, and upregulated HO-1 in CD4+ T cells by activating C-Raf–ERK1/2–Nrf2 pathway via induction of reactive oxygen species generation. In a trimellitic anhydride-induced AD-like mouse model, both topical and oral MQL ameliorated AD symptoms by suppressing Th2 immune responses. Our results suggest that MQL is a potential therapeutic agent for CD4+ T cell-mediated diseases, including allergic diseases.

Item Type: Article
Subjects: Research Scholar Guardian > Agricultural and Food Science
Depositing User: Unnamed user with email support@scholarguardian.com
Date Deposited: 29 Sep 2023 12:39
Last Modified: 29 Sep 2023 12:39
URI: http://science.sdpublishers.org/id/eprint/1457

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