Antioxidant Potential of Plumieride against CCl4-Induced Peroxidative Damage in Rats

Singh, Dharmendra and Arya, Priya and Sharma, Ashutosh and Aggarwal, Ved and Dobhal, Mahabeer and Gupta, Radhey (2014) Antioxidant Potential of Plumieride against CCl4-Induced Peroxidative Damage in Rats. Antioxidants, 3 (4). pp. 798-813. ISSN 2076-3921

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Abstract

In search of a new potent as an antioxidant from natural sources, plumieride—an iridoid isolated from the methanol extract of the bark of Plumeria bicolor (family Apocynaceae) was evaluated for its antioxidant potential against CCl4-induced peroxidative damage in liver of rats. The antioxidant potential was evaluated by using hepatic tissue for SOD (superoxide dismutase), CAT (catalase), GSH (reduced glutathione), GPx (glutathione peroxidase), GR (glutathione reductase) and LPO (lipid peroxidation) alongwith the concomitant blood serum for AST & ALT (aspartate and alanine transaminases), GGT (gamma glutamyl transpeptidase), ALP (alkaline phosphatase), total bilirubin and total protein contents. All the biochemical parameters were significantly (p ≤ 0.001) altered by CCl4 (0.3 mL/kg body weight/twice a week, intra-peritoneally for 30 days). Simultaneously, oral treatment with plumieride (5, 10 and 20 mg/kg body weight/day for 30 days), restored all the parameters towards a normal level, remarkably. The histological findings of liver sections further corroborated the antioxidant potential of plumieride compared with standard drug-silymarin. In conclusion, plumieride consists of sugar molecules, which have alcoholic groups. Therefore, the alcoholic groups of sugar increase its antioxidant potential through intermolecular hydrogen bonding along with the thiol(SH) group of non-protein thiols and enzymes resulting in the restoration of the antioxidant system. Therefore, it might be considered a natural antioxidant against peroxidative damage in rats.

Item Type: Article
Subjects: Research Scholar Guardian > Agricultural and Food Science
Depositing User: Unnamed user with email support@scholarguardian.com
Date Deposited: 06 Jul 2023 04:46
Last Modified: 29 Jan 2024 05:52
URI: http://science.sdpublishers.org/id/eprint/1280

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