Evaluation of Mutagenic Effects of Monosodium Glutamate Using Allium cepa and Antimutagenic Action of Origanum majorana L. and Ruta chalepensis Medical Plants

At the present study, Allium cepa root tips were collected during 2,6 and 24 hrs after treated with selected concentrations (1.0,3.0,5.0 and 7.0 g/L) of Mono-Sodium Glutamate (MSG) that used as flavour enhancer in foods. MSG induced mitodepression chromosomal aberrations such as bridges, fragments, disturbance, sticky chromosomes and other morphological abnormalities like enlargement cells. In this study we amid to determine the inhibitory effect of oil extract (1.25 µl/ml) from two medical plant species Origanium majorana L. and Ruta chalepensis on this food additive. Our results demonstrated that these extracts have the potency to suppress MSG by increasing of mitotic index and reduction of the chromosomal aberration and thus could be a promising antimutagenic and antigenotoxic potential.