Evaluating Second-line ART Efficacy in Pediatric HIV1 Infections: A Study at Albert Royer Children's Hospital

Baïdy, Dieye and Amadou, Diop and Ahmet, Niang Aïssatou and Abdoulaye, Sonko Mouhamadou and Habibou, Sarr and Fatoumata, Diallo and Gora, L. O. and Roughyatou, K. A. and Halimatou, Diop-Ndiaye and Coumba, Toure-Kane and Fafa, Cisse Moussa and Iyane, Sow Ahmad and Bouh, Boye Cheikh Saad and Lamine, Dia Mouhamadou (2023) Evaluating Second-line ART Efficacy in Pediatric HIV1 Infections: A Study at Albert Royer Children's Hospital. Journal of Advances in Microbiology, 23 (12). pp. 36-43. ISSN 2456-7116

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Introduction: In developing countries, around 15% of children infected with the Human Immunodeficiency Virus (HIV) have access to early diagnosis, and 28% are eligible for antiretroviral treatment (ART). The evaluation studies carried out in Senegal have been limited to children on first-line ART. The main objective of our study was to evaluate the efficacy of second-line ART.

Methodology: Data were collected at 3 different sites. This was a retrospective, longitudinal and analytical study, conducted from March 4 to August 28, 2015. The study population consisted of 65 HIV1-infected children. BD FACSCountTM Flow Cytometer for TCD4 lymphocyte counting. For genotyping, 2 sets of PCRs were required. Data were entered and analysed using Word/Excel 2013 and Epi-info7 software.

Results: We had 43 boys and 22 girls, giving a sex ratio of 1.95. The extreme ages were 5 and 15 years, and the mean age was 11.43 years. The majority belonged to stage 4 and 2 of the WHO classification. The clinical evolution was favourable in 86.15%, unfavourable in 3.07% and unspecified in 10.76%. We found 9 genotypes and recombinant forms; 80% of the strains were sequenced.

Discussion: The general aim of ART is the same as in adults. Clinical stages were not specified in 15.38% of cases. In total, 58.46% had an excellent immunovirological response. We conclude from this that a good IR doesn’t mean a good immunovirological evolution. Initiation of ART should be guided by genotyping.

Conclusion-Recommendations: ART reduced morbidity and mortality. Our study showed a virological failure rate of 21.53% and an IR rate of 86.15%.

Item Type: Article
Subjects: Research Scholar Guardian > Biological Science
Depositing User: Unnamed user with email support@scholarguardian.com
Date Deposited: 21 Dec 2023 08:30
Last Modified: 21 Dec 2023 08:30
URI: http://science.sdpublishers.org/id/eprint/2458

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