A Review on Bioactivities of Honey Bee Venom

The honey bee (Apis mellifera) is one of the world’s most advantageous creepy crawlies, because it
plays a basic part in numerous earthbound environments. The use of honeybee products has been
documented for thousands of years in many cultures for the treatment of human diseases, and their
healing properties have been documented in many religious texts. The present study sets out to
compile information on the history, chemical composition and scientific evidence concerning bee
venom research. The promising bioactivities have the potential to provide practical directions for
further investigation. PubMed database, Google Scholar Library, research articles, books, and
relevant web pages have been accessed to accumulate data so that the updated information included
in this study is as current as possible. At least 18 pharmacologically active components including
various enzymes, peptides, and amines are present in bee venom. Medicinal use of bee venom
therapy wields significant in vivo and in vitro outcomes to some extent mitigate the effects of
Parkinson’s disease, Alzheimer’s disease, HIV, arthritis, liver fibrosis, cancer, tumors, fibrotic
diseases, Lyme disease, etc. The effects of bee venom were the first documented in 1888 with the
publication of a European clinical study conducted on its impact on rheumatism. According to a study
published in the journal, bee venom has been used to treat various conditions for centuries. Such
research activities confirm the therapeutic effectiveness of bee venom and as a potential future
biomedicine.