ANTI-DIABETIC POTENTENTAL OF Spatoglossum asperum (BROWN SEAWEED); INSILICO MODEL

SEKAR, ANDREWS and CHELLADURAI, GURUSAMY and VAITHILINGAM, SUBRAMANIYAN and PANDIAN, ARJUN and SIVALINGAM, AZHAGU MADHAVAN and SIVAMANI, GANESAN (2022) ANTI-DIABETIC POTENTENTAL OF Spatoglossum asperum (BROWN SEAWEED); INSILICO MODEL. UTTAR PRADESH JOURNAL OF ZOOLOGY, 43 (19). pp. 48-57. ISSN 0256-971X

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Abstract

This study used GC-MS analysis and computational biology to examine the diabetic effect of bioactive substances obtained from brown seaweed. Using AutoDock/Vina in Pymol 4.2, the molecular docking of Spatoglossum asperum on the human PPAR- protein was determined and compared to that of the well-known PPAR- agonist Gilbenclamide. The analysis the active components of seaweed extracts is the main focus of the current investigation. 12 substances were discovered using GC-MS analysis and evaluated using AutoDock/Vina against PPAR. Docking tests showed that the existing phytochemical 9-Octadecenoic Acid (Z)-, Octadecyl Ester, obtained from seaweed, has the highest fitness score of -398.9 kcal/mol and may therefore be a potent anti-diabetic drug. This study could result in the creation of brand-new marine nutraceuticals that use brown seaweed to treat a number of diseases.

Item Type: Article
Subjects: Research Scholar Guardian > Biological Science
Depositing User: Unnamed user with email support@scholarguardian.com
Date Deposited: 16 Nov 2023 05:04
Last Modified: 16 Nov 2023 05:04
URI: http://science.sdpublishers.org/id/eprint/1936

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