Levels of Interleukin‐18 in Saliva and Gingival Crevicular Fluid in Patients with Chronic Periodontitis and Healthy Subjects

Esfahrood, Zeinab Rezaei and Zare, Davood and Reza, Javad Zavar and Rahmanian, Farzaneh (2016) Levels of Interleukin‐18 in Saliva and Gingival Crevicular Fluid in Patients with Chronic Periodontitis and Healthy Subjects. Annual Research & Review in Biology, 10 (3). pp. 1-6. ISSN 2347565X

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Abstract

Aims: Cytokines play a key role in the initiation and progression of chronic periodontitis. This study aimed to measure and compare the levels of Interleukin (IL)-18 in both saliva and gingival cervicular fluid (GCF) of patients with chronic periodontitis and healthy controls.

Study Design: In this descriptive study we assessed the levels of IL-18 in unstimulated whole saliva and GCF samples among patients with chronic periodontitis and individuals with healthy periodontium.

Place and Duration of Study: Department of periodontology and Department of biochemistry, Services Institute of Shahid Sadughi University of Medical Science, between May 2015 and Jan 2016.
Methodology: Thirty two subjects were divided into two groups; 16 individuals with healthy periodontium and 16 patients with chronic periodontitis. GCF and saliva samples were obtained. The concentrations of IL-18 in GCF and saliva were determined using ELISAs.
Results: There was no significant difference between the levels of IL-18 in saliva and GCF samples among the study groups (Respectively P= 0.44 and P= 0.38). Also, significantly different was not observed while comparing the IL-18 level of saliva with the IL-18 level of GCF in both healthy subjects (P= 0.8) and patients with chronic periodontitis (P= 0.61).
Conclusion: Similar levels of IL-18 among study groups suggested that levels of IL-18 in saliva and GCF cannot be used as a predictable biomarker for early diagnosis of periodontal disease.

Item Type: Article
Subjects: Research Scholar Guardian > Biological Science
Depositing User: Unnamed user with email support@scholarguardian.com
Date Deposited: 07 Oct 2023 09:26
Last Modified: 07 Oct 2023 09:26
URI: http://science.sdpublishers.org/id/eprint/1510

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